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This all-encompassing analysis allows investigation of intactness and component distribution of the excised hair bulb in three dimensions. Furthermore, cyanoacrylate skin surface biopsies, which are generally used to determine the extent of follicular penetration, were imaged by a novel complementary analytical approach combining confocal Raman microscopy and optical profilometry. Based on the evaluation of human and porcine Raman spectra optical similarity for both species was successfully confirmed. In this study, we applied confocal Raman microscopy as a chemically selective imaging technique to compare human and porcine follicle composition and to visualize component distribution within follicle cross-sections. However, a comparison of human and porcine follicles in terms of chemical composition has not been performed so far. In this area of research, excised pig ear is a widely accepted in vitro model to evaluate penetration of drug delivery into hair follicles. They provide facilitated penetration into the skin and a high potential to serve as a drug depot. ![]() Abstract Hair follicles have recently gained a lot of interest for dermal drug delivery.
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